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Benefits for Interstitial Cystitis.

As individuals with Interstitial Cystitis (IC) search for effective relief, D-mannose, a naturally occurring sugar, has emerged as a promising therapeutic option. In fact, people often use D-mannose, vitamin C, and cranberry together to treat urinary tract infections (UTIs). However, they can cause problems for sensitive IC bladders. In this article, we will delve into the benefits of using only D-mannose and IC symptom management.

All about D-mannose.

Listen to Femetry’s own Dr. Victoria Scott discuss the many benefits of D-mannose.

Understanding IC.

Researchers have so much left to discover about IC, or Painful Bladder Syndrome. They still don’t know the cause of the condition, but have several theories. One hypothesis points to inflammation of the bladder wall. This results in a range of symptoms that significantly impact comfort and quality of life, and make treatment challenging.

Most IC patients look towards a multidisciplinary approach, including diet changes and supplementation. Learn more about how your diet could be triggering IC flares: The IC diet: 7 foods to avoid.

Common symptoms of Interstitial Cystitis include pelvic pain, frequent urination, urgency, and discomfort during sexual intercourse. An IC flare is often unpredictable and extremely painful. Without a universally effective treatment, many IC sufferers are frustrated.

Did you know…

D-mannose naturally occurs in a variety of fruits and vegetables.

Benefits of D-mannose for IC support.

D-mannose is a sugar found in many fruits, including cranberries, peaches, apples, and even in the human body. It helps to prevent bacteria from “sticking” to the wall of the bladder. D-mannose has gained attention in recent years for its potential therapeutic effects on urinary tract health.

Here’s a breakdown of a few benefits of D-mannose for IC:

  • Prevents bacterial sticking
  • Helps ease inflammation
  • Promotes a healthy urinary tract


Prevents bacterial sticking.

Research suggests that D-mannose may help prevent recurrent UTIs by inhibiting bacterial adhesion. So, what does that have to do with IC?

Well, the two conditions actually share quite a few similarities. IC mimics a UTI and often results in a misdiagnosis as such. Moreover, many patients with IC have frequent, recurrent UTIs.

Currently, limited clinical studies have investigated the efficacy of D-mannose specifically for IC. However, some studies have explored its benefits for recurrent UTIs and it might be beneficial to help with IC.

D-mannose helps prevent bacteria from sticking to the bladder wall, which is a major advantage for IC. D-mannose works by binding to bacteria and stopping them from sticking to the bladder. Instead, urine flushes out the harmful bacteria that could cause infection or irritation.

Helps ease inflammation.

As mentioned above, the cause of IC is presently unknown. We don’t know if inflammation is the cause or just a symptom of IC. However, we do know that chronic inflammation is a hallmark of the condition.

D-mannose has demonstrated anti-inflammatory properties, potentially contributing to the reduction of inflammation in the bladder. D-mannose can help ease inflammation and relieve symptoms, like pain and discomfort in IC.

Promotes a healthy urinary tract.

D-mannose promotes the overall health of the urinary tract. It can act as a prebiotic, fostering the growth of “good” bacteria.

D-mannose also supports the integrity of the mucosal lining. A healthy mucosal barrier is crucial for protecting the bladder wall from irritants and pathogens. For an IC bladder, this could help soothe flares and minimize their occurrence.

D-mannose may offer support for people struggling with IC. It prevents bacteria from adhering to the bladder wall, causing irritation and infection. It may also be beneficial in soothing pain and discomfort associated with IC.

Many choose a multifaceted, holistic approach to manage the complex nature of IC. You can try combining D-mannose with other methods, like changing your diet or doing specific pelvic floor exercises that help relax the bladder.

There is no single solution for IC. Finding what works for you is part of the healing process. Consult a healthcare professional to explore what treatment options might be right for you.

For more information about our potent ingredients, visit our Ingredient Glossary.

  1. Is D-mannose good for Interstitial Cystitis?
    1. D-mannose may offer some support from Interstitial Cystitis symptoms by soothing bladder discomfort. D-mannose clings to “bad” bacteria and prevents it from sticking to the bladder wall, causing irritation and infection. It also promotes a healthy urinary tract by promoting the growth of “good” bacteria.
  2. Does D-mannose irritate the bladder?
    1. D-mannose actually helps soothe an irritated bladder. Most commonly used to soothe a UTI, D-mannose effectively balances the microflora in the urinary tract. It stops harmful bacteria from sticking to the bladder and causing irritation, while promoting the growth of beneficial bacteria.
  3. Does D-mannose make urine more acidic?
    1. The body converts D-mannose to glucose. High glucose consumption tends to mean lower urine pH, so the urine shouldn’t be more acidic. Take precaution when adding any new supplement to your diet and consult a healthcare professional first.
  4. Is it okay to take D-mannose every day?
    1. D-mannose is generally okay to take every day. It’s naturally present in many of the foods we eat and considered safe to take as a supplement. However, remember to consider any existing health issues and talk to a doctor if you have any worries.
  5. Is it better to take D-mannose tablets or powder?
    1. That depends entirely on you. D-mannose as a powder allows for you to control the dosage and may prove to be more effective. As a tablet, D-mannose offers convenience to take on-the-go.

Urinary Cleanse & Flora Balance

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Clinical doses of powerful ingredients, like aloe vera, hyaluronic acid, quercetin, and ashwagandha. This multipoint formula supports the underlying causes of IC, supports a healthy inflammatory response and bladder lining, and helps to keep stress at bay.

Learn more
Urinary cleanse and flora balance lifestyle display